Publications

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• Journal Articles

  • Surface Modification of E. coli Outer Membrane Vesicles with Glycosylphosphatidylinositol-Anchored Proteins: Generating Pro/Eukaryote Chimera Constructs. Zaruba M, Roschitz L, Sami H, Ogris M, Gerner W, Metzner C. Membranes (Basel). 2021 Jun 4;11(6):428. doi: 10.3390/membranes11060428. PMID: 34199851
  • Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air-Blood Barrier Crossing. Taschauer A, Polzer W, Pöschl S, Metz S, Tepe N, Decker S, Cyran N, Scholda J, Maier J, Bloß H, Anton M, Hofmann T, Ogris M, Sami H. ACS Appl Mater Interfaces. 2020 Jul 8;12(27):30095-30111. doi: 10.1021/acsami.0c06608. Epub 2020 Jun 23. PMID: 32515194
  • Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway. Maier J, Elmenofi S, Taschauer A, Anton M, Sami H, Ogris M. PLoS One. 2019 Dec 20;14(12):e0226570. doi: 10.1371/journal.pone.0226570. eCollection 2019. PMID: 31860685
  • Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung.
    Taschauer A, Polzer W, Alioglu F, Billerhart M, Decker S, Kittelmann T, Geppl E, Elmenofi S, Zehl M, Urban E, Sami H, Ogris M. Mol Ther Nucleic Acids. 2019 Dec 6;18:774-786. doi: 10.1016/j.omtn.2019.10.009. Epub 2019 Oct 18. PMID: 31734558
  • Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration.
    Thanki K, van Eetvelde D, Geyer A, Fraire J, Hendrix R, Van Eygen H, Putteman E, Sami H, de Souza Carvalho-Wodarz C, Franzyk H, Nielsen HM, Braeckmans K, Lehr CM, Ogris M, Foged C. J Control Release. 2019 Sep 28;310:82-93. doi: 10.1016/j.jconrel.2019.08.004. Epub 2019 Aug 6. PMID: 31398360
  • Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis. Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S. Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25. PMID: 31031016
  • Firefly Luciferase-Based Reporter Gene Assay for Investigating Nanoparticle-Mediated Nucleic Acid Delivery.
    Müller K, Ogris M, Sami H. Methods Mol Biol. 2019;1943:227-239. doi: 10.1007/978-1-4939-9092-4_15. PMID: 30838620
  • Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor Targeting of Nucleic Acids.
    Rödl W, Taschauer A, Schaffert D, Wagner E, Ogris M. Methods Mol Biol. 2019;1943:83-99. doi: 10.1007/978-1-4939-9092-4_6. PMID: 30838611
  • Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis.
    Groza D, Gehrig S, Kudela P, Holcmann M, Pirker C, Dinhof C, Schueffl HH, Sramko M, Hoebart J, Alioglu F, Grusch M, Ogris M, Lubitz W, Keppler BK, Pashkunova-Martic I, Kowol CR, Sibilia M, Berger W, Heffeter P. Oncoimmunology. 2018 Feb 16;7(5):e1424676. doi: 10.1080/2162402X.2018.1424676. eCollection 2018. PMID: 29721389 Free PMC article.
  • In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots.
    Deglmann CJ, Błażków-Schmalzbauer K, Moorkamp S, Wallmichrath J, Giunta RE, Rogach AL, Wagner E, Baumeister RG, Ogris M. Arch Plast Surg. 2018 Mar;45(2):111-117. doi: 10.5999/aps.2017.01487. Epub 2018 Mar 5. PMID: 29506330 Free PMC article.
  • Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors.
    Urbiola K, Blanco-Fernández L, Ogris M, Rödl W, Wagner E, Tros de Ilarduya C. J Pers Med. 2018 Jan 9;8(1):4. doi: 10.3390/jpm8010004. PMID: 29315261 Free PMC article.
  • Reintroducing the Sodium-Iodide Symporter to Anaplastic Thyroid Carcinoma.
    Schmohl KA, Dolp P, Schug C, Knoop K, Klutz K, Schwenk N, Bartenstein P, Nelson PJ, Ogris M, Wagner E, Spitzweg C. Thyroid. 2017 Dec;27(12):1534-1543. doi: 10.1089/thy.2017.0290. Epub 2017 Nov 10. PMID: 29032724
  • Multimodal Fluorescence and Bioluminescence Imaging Reveals Transfection Potential of Intratracheally Administered Polyplexes for Breast Cancer Lung Metastases.
    Geyer A, Taschauer A, Alioglu F, Anton M, Maier J, Drothler E, Simlinger M, Yavuz S, Sami H, Ogris M. Hum Gene Ther. 2017 Dec;28(12):1202-1213. doi: 10.1089/hum.2017.137. Epub 2017 Oct 26. PMID: 28874076
  • Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes.
    Urnauer S, Klutz K, Grünwald GK, Morys S, Schwenk N, Zach C, Gildehaus FJ, Rödl W, Ogris M, Wagner E, Spitzweg C. J Gene Med. 2017 May;19(5). doi: 10.1002/jgm.2957. PMID: 28423213
  • Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene. Schmohl KA, Gupta A, Grünwald GK, Trajkovic-Arsic M, Klutz K, Braren R, Schwaiger M, Nelson PJ, Ogris M, Wagner E, Siveke JT, Spitzweg C. Oncotarget. 2017 May 16;8(20):33393-33404. doi: 10.18632/oncotarget.16499. PMID: 28380420
  • Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells. Wittig A, Gehrke H, Del Favero G, Fritz EM, Al-Rawi M, Diabaté S, Weiss C, Sami H, Ogris M, Marko D. Nanomaterials (Basel). 2017 Jan 13;7(1):18. doi: 10.3390/nano7010018. PMID: 28336852
  • Fluorescence- and computed tomography for assessing the biodistribution of siRNA after intratracheal application in mice.
    Geyer A, Lorenzer C, Gehrig S, Simlinger M, Winkler J, Sami H, Ogris M. Int J Pharm. 2017 Jun 20;525(2):359-366. doi: 10.1016/j.ijpharm.2017.02.025. Epub 2017 Feb 14. PMID: 28213277
  • Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts.
    Deglmann CJ, Błażków-Schmalzbauer K, Moorkamp S, Susha AS, Herrler T, Giunta RE, Wagner E, Rogach AL, Baumeister RG, Ogris M. Ann Plast Surg. 2017 Feb;78(2):217-222. doi: 10.1097/SAP.0000000000000930. PMID: 27845964
  • Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation. Kessler SM, Laggai S, Van Wonterghem E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK. Front Physiol. 2016 Jul 29;7:328. doi: 10.3389/fphys.2016.00328. eCollection 2016. PMID: 27489546
  • Biopharmaceuticals and gene vectors opening new avenues in cancer immune therapy. Sami H, Ogris M. Ther Deliv. 2016 Jul;7(7):419-22. doi: 10.4155/tde-2016-0032. PMID: 27403627
  • Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.
    Kessler SM, Laggai S, Van Wonterg E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK. Front Physiol. 2016 Apr 25;7:147. doi: 10.3389/fphys.2016.00147. eCollection 2016. PMID: 27199763
  • Up-Scaled Synthesis and Characterization of Nonviral Gene Delivery Particles for Transient In Vitro and In Vivo Transgene Expression.
    Taschauer A, Geyer A, Gehrig S, Maier J, Sami H, Ogris M. Hum Gene Ther Methods. 2016 Jun;27(3):87-97. doi: 10.1089/hgtb.2016.027. PMID: 27169568
  • Receptor Crosslinking in Drug Delivery: Detour to the Lysosome? Ogris M, Sami H. Mol Ther. 2015 Dec;23(12):1802-4. doi: 10.1038/mt.2015.207. PMID: 26689121
  • Simultaneous determination of active component and vehicle penetration from F-DPPC liposomes into porcine skin layers.
    Mahrhauser DS, Reznicek G, Gehrig S, Geyer A, Ogris M, Kieweler R, Valenta C. Eur J Pharm Biopharm. 2015 Nov;97(Pt A):90-5. doi: 10.1016/j.ejpb.2015.10.008. Epub 2015 Oct 19. PMID: 26493713
  • Assessment of Raman spectroscopy as a fast and non-invasive method for total stratum corneum thickness determination of pig skin.
    Mahrhauser DS, Nagelreiter C, Gehrig S, Geyer A, Ogris M, Kwizda K, Valenta C. Int J Pharm. 2015 Nov 10;495(1):482-484. doi: 10.1016/j.ijpharm.2015.09.018. Epub 2015 Sep 14. PMID: 26383843
  • Evaluation of improved PAMAM-G5 conjugates for gene delivery targeted to the transferrin receptor.
    Urbiola K, Blanco-Fernández L, Navarro G, Rödl W, Wagner E, Ogris M, Tros de Ilarduya C. Eur J Pharm Biopharm. 2015 Aug;94:116-22. doi: 10.1016/j.ejpb.2015.05.007. Epub 2015 May 22. PMID: 26004821
  • Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics.
    Gehrig S, Sami H, Ogris M. Ther Deliv. 2014 Dec;5(12):1275-96. doi: 10.4155/tde.14.87. PMID: 25531929
  • Hütz K, Mejías-Luque R, Farkasova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Schneider MR, Blum H, Wagner E, Jung A, Gerhard M. The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. Carcinogenesis. 2014 Apr;35(4):942-50.
  • Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C. EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene. Mol Ther Nucleic Acids. 2013 Nov 5;2:e131. doi: 10.1038/mtna.2013.58.
  • Ogris M. Gene therapy in the clinics: shifting into the next gear. Ther Deliv. 2013 Nov;4(11):1359-63. doi: 10.4155/tde.13.109.
  • Grünwald GK, Vetter A, Klutz K, Willhauck MJ, Schwenk N, Senekowitsch-Schmidtke R, Schwaiger M, Zach C, Wagner E, Göke B, Holm PS, Ogris M, Spitzweg C. Systemic Image-Guided Liver Cancer Radiovirotherapy Using Dendrimer-Coated Adenovirus Encoding the Sodium Iodide Symporter as Theranostic Gene. J Nucl Med. 2013 Jul 10. [Epub ahead of print]
  • Kopp F, Schnoedt M, Haase R, Wagner E, Roidl A, Ogris M (2013) De-targeting by miR-143 decreases unwanted transgene expression in non-tumorigenic cells. Gene Ther. 2013 Jun 27. doi: 10.1038/gt.2013.37. [Epub ahead of print]
  • Schaffert D, Ogris M (2013) Nucleic Acid Carrier Systems Based on Linear Polyethylenimine for the Treatment of Metastatic Tumors. Curr Med Chem. 2013 May 27. [Epub ahead of print]
  • Haase R, Magnusson T, Su B, Kopp F, Wagner E, Lipps H, Baiker A, Ogris M (2013) Generation of a tumor- and tissue-specific episomal non-viral vector system. BMC Biotechnol. 2013 Jun 4;13(1):49. [Epub ahead of print]
  • Viola JR, Rafael DF, Wagner E, Besch R, Ogris M. (2013) Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids. J Drug Deliv. 2013;2013:897348. doi: 10.1155/2013/897348.
  • Ogris M, Roidl A (2013) Targeted therapy of cancer stem cells: science or fiction. Ther Deliv. 2013 Feb;4(2):135-8. doi: 10.4155/tde.12.153.
  • Vetter A, Virdi KS, Espenlaub S, Rödl W, Wagner E, Holm PS, Scheu C, Kreppel F, Spitzweg C, Ogris, M (2013) Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF Receptor.Mol Pharm. 2013 Feb 4;10(2):606-18. doi: 10.1021/mp300366f.
  • Rödl, W., Schaffert, D., Wagner, E., Ogris, M (2013) Synthesis of polyethylenimine-based nanocarriers for systemic tumor targeting of nucleic acids. Methods Mol Biol. 2013;948:105-20.
  • Terziyska N, Alves CC, Groiss V, Schneider K, Farkasova K, Ogris M, Wagner E, Ehrhardt H, Brentjens RJ, Zur Stadt U, Horstmann M, Quintanilla-Martinez L, Jeremias I (2012) In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. PLoS ONE. 2012;7(12):e52798. doi: 10.1371/journal.pone.0052798. Epub 2012 Dec 31.
  • Su, B., Cengizeroglu, A., Farkasova, K., Viola, J.R., Anton, M., Ellwart, J.W., Haase, R., Wagner, E., Ogris, M. (2012) Systemic TNFα Gene Therapy Synergizes With Liposomal Doxorubicine in the Treatment of Metastatic Cancer Mol. Ther, 2013 Feb;21(2):300-8.
  • Mickler, F.M., Möckl, L., Ruthardt, N., Ogris, M., Wagne,r E., Bräuchle, C. (2012) Tuning nanoparticle uptake: live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand. Nano Lett. 2012 Jul;12(7):3417-23.
  • Abourbeh, G., Shir, A., Mishani, E., Ogris, M., Rödl, W., Wagner, E., Levitzki, A. (2012) PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors IUBMB Life. 2012 Apr;64(4):324-30.
  • Buyens, K., De Smedt, S.C., Braeckmans, K., Demeester, J., Peeters, L., van Grunsven, L.A., de Mollerat du Jeu, X., Sawant. R., Torchilin, V., Farkasova, K., Ogris, M., Sanders, N.N. (2012) Liposome based systems for systemic siRNA delivery: stability in blood sets the requirements for optimal carrier design. J Control Release. 2012 Mar;158(3):362-70.
  • Ogris, M., Wagner, E. Synthesis of linear polyethylenimine and use in transfection (2012) Cold Spring Harb Protoc. 2012 Feb;2012(2):246-50.
  • Klutz, K., Willhauck, M.J., Dohmen, C., Wunderlich, N., Knoop, K., Zach, C., Senekowitsch-Schmidtke, R., Gildehaus, F.J., Ziegler, S., Fürst, S., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2011) Image-guided tumor-selective radioiodine therapy of liver cancer after systemic nonviral delivery of the sodium iodide symporter gene, Hum Gene Ther. 2011 Dec;22(12):1563-74
  • Magnusson, T., Haase, R., Schleef, M., Wagner, E., Ogris, M. (2011) Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations, J Gene Med. 2011 Jul;13(7-8):382-91
  • Ogris, M., Wagner, E. (2011) To be targeted: is the magic bullet concept a viable option for synthetic nucleic Acid therapeutics?, Hum Gene Ther. 2011 Jul;22(7):799-807
  • Shir, A., Levitzki, A., Wagner, E., Klein, S., Ogris, M. (2011) Nucleic Acid-Based Therapeutics For Glioblastoma. Anticancer Agents Med Chem. 2011 Oct;11(8):693-9.
  • Schaffert, D., Ogris, M. (2011) SiRNA therapeutics: chances, pitfalls and future potential. Therapeutic Delivery 2011 Sep;2(9):1101-4.
  • Abel, T., Kreppel, F., Ogris, M., Büning, H. (2011) [When gene vectors are equipped with the correct key, the cell surface can be targeted], Pharm Unserer Zeit. 2011 May;40(3):225-38
  • Nie, Y., Schaffert, D., Rödl, W., Ogris, M., Wagner, E., Günther, M. (2011) Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy, J Control Release. 2011 May 30;152(1):127-34
  • Dussmann, P., Pagel, J.I., Vogel, S., Magnusson, T., Zimmermann, R., Wagner, E., Schaper, W., Ogris, M., Deindl, E. (2011) Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing, BMC Dev Biol. 2011 May 20;11(1):28
  • Kasper, J.C., Schaffert, D., Ogris, M., Wagner, E., Friess, W. (2011) Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability-A step closer from promising technology to application, J Control Release. 2011 May 10;151(3):246-55
  • Schaffert, D., Kiss, M., Rödl, W., Shir, A., Levitzki, A., Ogris, M., Wagner, E. (2011) Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier, Pharm Res. 2011 Apr;28(4):731-41
  • Klutz, K., Schaffert, D., Willhauck, M.J., Grünwald, G.K., Haase, R., Wunderlich, N., Zach, C., Gildehaus, F.J., Senekowitsch-Schmidtke, R., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2011) Epidermal Growth Factor Receptor-targeted (131)I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene, Mol Ther. 2011 Apr;19(4):676-85
  • Schäfer, A., Pahnke, A., Schaffert, D., van Weerden, W.M., de Ridder, C.M., Rödl, W., Vetter, A., Spitzweg, C., Kraaij, R., Wagner, E., Ogris, M. (2011) Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation, Hum Gene Ther. 2011 Dec;22(12):1463-73
  • Stahnke, S., Lux, K., Uhrig, S., Kreppel, F., Hösel, M., Coutelle, O., Ogris, M., Hallek, M., Büning, H. (2011) Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles, Virology. 2011 Jan 5;409(1):77-83
  • Kasper, J.C., Schaffert, D., Ogris, M., Wagner, E., Friess, W. (2011) The establishment of an up-scaled micro-mixer method allows the standardized and reproducible preparation of well-defined plasmid/LPEI polyplexes, Eur J Pharm Biopharm. 2011 Jan;77(1):182-5
  • Shir, A., Ogris, M., Rödl, W., Wagner, E., Levitzki, A. (2011) EGFR-homing dsRNA activates cancer targeted immune response and eliminates disseminated EGFR over-expressing tumors in mice, Clin Cancer Res. 2011 Mar 1;17(5):1033-43
  • Büning, H., Baum, C., Ehrhardt, A.,, Nettelbeck, D.M., Ogris, M. (2011) 17th Annual Meeting of the German Society for Gene Therapy, Meeting Report, Therapeutic Delivery 2011;2(1):19-24 (free access)
  • Ogris, M. (2010) Cancer gene therapies come of age, Therapeutic Delivery 2010;1(2):211-214 (free access)
  • Rupprecht, S., Hagedorn, C,, Seruggia, D., Magnusson, T., Wagner, E., Ogris, M., Lipps, H.J. (2010)Controlled removal of a nonviral episomal vector from transfected cells, Gene. 2010 Oct 15;466(1-2):36-42
  • Ogris, M. (2010) Nucleic acid therapeutics – Concepts for targeted delivery to solid tumors, Therapeutic delivery 2010;1(1):91-107
  • Rogach, A.L., Ogris, M. (2010) Near-infrared emitting semiconductor quantum dots for tumor imaging and targeting, Curr Opin Mol Ther. 2010 Jun;12(3):331-9
  • Navarro, G., Maiwald, G., Haase, R., Rogach, A.L., Wagner, E., de Ilarduya C.T., Ogris, M. (2010) Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery, J Control Release. 2010 Aug 17;146(1):99-105
  • Espenlaub, S., Corjon, S., Engler, T., Fella, C., Ogris, M., Wagner, E., Kochanek, S., Kreppel, F. (2010) Capsomere-specific fluorescent labeling of adenovirus vector particles allows for detailed analysis of intracellular particle trafficking and of the performance of bioresponsive bonds for vector capsid modifications, Hum Gene Ther. 2010 Sep;21(9):1155-67
  • Haase, R., Argyros, O., Wong, S.P., Harbottle, R.P., Lipps, H.J., Ogris, M., Magnusson, T., Vizoso Pinto, M.G., Haas, J., Baiker, A. (2010) pEPito: a significantly improved non-viral episomal expression vector for mammalian cells, BMC Biotechnology 2010 Mar 15;10:20
  • Thoenes, L., Höhn, M., Kashirin, R., Ogris, M., Arnold, G.J., Wagner, E., Günther, M. (2010) In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy, J Proteomics. 2010 May 7;73(7):1342-54
  • Ruß, V., Fröhlich, T., Li, Y., Halama, A., Ogris, M., Wagner, E. (2010) Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes, J Gene Med. 2010 Feb;12(2):180-93
  • Zintchenko, A., Susha, A.S., Concia, M., Feldmann, J., Wagner, E., Rogach, A.L., Ogris, M. (2009) Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals, Mol Ther. 2009 Nov;17(11):1849-56
  • Klutz, K., Ruß, V., Willhauck, M.J., Wunderlich, N., Zach, C., Gildehaus, F.J., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2009) Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene, Clin Cancer Res. 2009 Oct 1;15(19):6079-86
  • Meyer, M., Dohmen, C., Philipp, A., Kiener, D., Maiwald, G., Scheu, C., Ogris, M., Wagner, E. (2009)Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate, Mol Pharm. 2009 Jun-Jul;6(3):752-62
  • Ruß, V., Günther, M., Halama, A., Ogris, M., Wagner, E. (2008) Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery, J Control Release. 2008 Dec 8;132(2):131-40
  • Peller, M., Schwerdt, A., Hossann, M., Reinl, H.M., Wang, T., Sourbron, S., Ogris, M., Lindner, L.H. (2008) MR characterization of mild hyperthermia-induced gadodiamide release from thermosensitive liposomes in solid tumors, Invest Radiol. 2008 Dec;43(12):877-92
  • Schwerdt, A., Zintchenko, A., Concia, M., Roesen N., Fisher K., Lindner L.H., Issels R., Wagner, E., Ogris, M. (2008) Hyperthermia induced targeting of thermosensitive gene carriers to tumors, Hum Gene Ther. 2008 Nov;19(11):1283-1292
  • Günther, M., Wagner, E., Ogris, M. (2008) Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy? , J. Cell. Mol. Med. 12: 2704-2716
  • Knorr, V., Ogris, M., Wagner, E. (2008) An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity, Pharm Res. 2008 Dec;25(12):2937-45
  • Fella, C., Walker, G. F., Ogris, M., Wagner, E. (2008) Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding., Eur J Pharm Sci. 2008 Aug;34(4-5):309-20.
  • Knorr, V., Ruß, V., Allmendinger L., Ogris, M., Wagner, E. (2008) Acetal Linked Oligoethylenimines for Use As pH-Sensitive Gene Carriers., Bioconjug Chem. 2008 Aug;19(8):1625-34
  • Cavallaro G., Scirè S., Licciardi M., Ogris, M., Wagner, E., Giammona G. (2008) Polyhydroxyethylaspartamide-spermine copolymers: Efficient vectors for gene delivery., J Control Release. 2008 Oct 6;131(1):54-63
  • Tietze, N., Pelisek, J., Philipp, A., Rödl, W., Merdan, T., Tarcha, P., Ogris, M., Wagner, E. (2008) Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran., Oligonucleotides.2008 Jun;18(2):161-74.
  • de Bruin, K.G., Fella, C., Ogris, M., Wagner, E., Ruthardt, N., Bräuchle, C. (2008) Dynamics of photoinduced endosomal release of polyplexes., J Control Release. 2008 Sep 10;130(2):175-82
  • Ruß, V., Elfberg, H., Thoma, C., Klöckner, J., Ogris, M., Wagner, E. (2008) Novel degradable oligoethylenimine-acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer., Gene Ther. 15, 18-29.
  • Ogris M, Kotha AK, Tietze N, Wagner E, Palumbo FS, Giammona G, Cavallaro G. (2007) Novel biocompatible cationic copolymers based on polyaspartylhydrazide being potent as gene vector on tumor cells. Pharm. Res. 24(12), 2213-2222
  • Fahrmeir, J., Günther, M., Tietze, N., Wagner, E., Ogris, M. (2007) Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo., J. Control. Rel. 122, 236-245
  • de Bruin, K., Ruthardt, N., von Gersdorff, K., Bausinger, R., Wagner, E., Ogris, M., Braeuchle, C. (2007)Cellular dynamics of EGF receptor-targeted synthetic viruses, Mol. Ther. 15(7), 1297-1305.
  • Meyer, M., Zintchenko, A., Ogris, M., Wagner, E. (2007) A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential, J. Gene Med. 9(9), 797-805.
  • Klöckner, J., Wagner, E., Ogris, M. (2006) Degradable Gene Carriers Based on Oligomerized Polyamines, Eur. J. Pharm. Sci. 29, 414-425.
  • Klöckner, J., Boeckle, S., Klöckner, J., Rödl, W., Ogris, M., Berg, K., Wagner, E. (2006) DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions, J. Control. Rel. 116, 115-122.
  • Klöckner, J., Bruzzano, S., Ogris, M., Wagner, E. (2006) Gene Carriers Based on Hexanediol Diacrylate-linked Oligoethylenimine: Effect of Chemical Structure of Polymer on Biological Properties, Bioconjug. Chem. 17(5), 1339-1345.
  • von Gersdorff, K., Sanders, N.N., Vandenbroucke, R., De Smedt, S.C., Wagner, E., Ogris, M. (2006) The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type, Mol. Ther. 14(5), 745-753.
  • Günther, M., Waxman, D. J., Wagner, E., Ogris, M. (2006) Effects of Hypoxia and Limited Diffusion in Tumor Cell Microenvironment on Bystander Effect of P450 Prodrug Therapy, Cancer Gene Ther. 13(8), 771-779.
  • Boeckle, S., Fahrmeir, J., Rödl, W., Ogris, M., Wagner, E. (2006) Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes, J. Control. Rel. 112, 240-248.
  • Zintchenko, A., Ogris, M., Wagner, E. (2006) Temperature Dependent Gene Expression Induced by PNIPAM-based Copolymers: Potential of Hyperthermia in Gene Transfer, Bioconjug. Chem. 17(3), 766-772.
  • Cavallaro, G., Campisi, M., Licciardi, M., Ogris, M., Giammona, G. (2006) Reversibly stable thiopolyplexes for intracellular delivery of genes., J Control Release 15(3), 322-334.
  • Bausinger, R., von Gersdorff, K., Braeckmans, K., Ogris, M., Wagner, E., Bräuchle, C., Zumbusch, A. (2006) The Transport of Nanosized Gene Carriers Unraveled by Live-Cell Imaging, Angew. Chem. 118, 1598-1602.
  • Ogris, M. (2006) Nucleic acid based therapeutics for tumor therapy, Anti-Cancer Agents in Medicinal Chemistry 6(6), 563-570.
  • Shir, A., Ogris, M., Wagner, E., Levitzki, A. (2006) EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice, PLoS Med. 3(1), e6.
  • von Gersdorff, K., Ogris, M., Wagner, E. (2005) Cryoconserved Shielded and EGF Receptor Targeted DNA Polyplexes: Cellular Mechanisms, European Journal of Pharmaceutics and Biopharmaceutics 60, 279-285.
  • Walker, G. F., Fella, C., Pelisek, J., Fahrmeir, J., Boeckle, S., Ogris, M., Wagner, E. (2005) Toward synthetic viruses: Endosomal pH triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo, Mol Ther 11(3), 418-425.
  • Günther, M., Wagner, E., Ogris, M. (2005) Specific targets in tumor tissue for the delivery of therapeutic genes, Curr Med Chem Anti-Canc Agents 5, 157-171.
  • Boeckle, S., Wagner, E., Ogris, M. (2005) C- versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes, J. Gene Med. 7, 1335-1347.
  • Lenter, M. C., Garidel P., Pelisek, J., Wagner, E., Ogris, M. (2004) Stabilized non-viral formulations for the delivery of MCP-1 gene into cells of the vasculoendothelial system, Pharm. Res. 21(4), 683-691.
  • Pelisek, J., Kühnl, A., Rolland, P.H., Mekkaoui, C., Fuchs, A., Walker, G. F., Ogris, M., Wagner, E., Nikol, S. (2004) Functional analysis of genomic DNA, cDNA and nucleotide sequence of the mature C-type natriuretic peptide gene in vascular cells, Arteriosclerosis, Thrombosis, Vascular Biol. 24, 1646-1651.
  • Boeckle, S., von Gersdorff, K., van der Piepen, S., Culmsee, C., Wagner, E., Ogris, M. (2004) Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer, J. Gene Med. 6, 1102-1111.
  • Smrekar B., Wightman L., Wolschek M.F., Lichtenberger, C., Ruzicka, R., Ogris, M., Rödl, W., Kursa, M., Wagner, E., Kircheis, R. (2003) Tissue-dependent factors affect gene delivery to tumors in vivo, Gene Ther. 10, 1079-1088.
  • Manzano A., Mohri Z., Sperber G., Ogris, M., Graham I., Dickson G., Owen, J. S. (2003) Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts), J Gene Med. 5(9), 795-802.
  • Ogris, M., Walker, G. F., Blessing, T., Kircheis, R., Wolschek, M., Wagner, E. (2003) Tumor-Targeted Gene Therapy: Strategies for Preparation of Ligand-Polyethylene Glycol-Polyethylenimine / DNA Complexes., J. Controlled Rel. 91, 173-181.
  • Kursa, M., Walker, G. F., Roessler, V., Ogris, M., Rödl, W., Kircheis, R., Wagner, E. (2003) Novel shielded Transferrin-Polyethylene Glycol-Polyethylenimine / DNA Complexes for Systemic Tumor-Targeted Gene Transfer, Bioconjug. Chem. 14, 222-231.
  • Ogris, M., Wagner, E. (2002) Tumor-targeted Gene Transfer with DNA Polyplexes., Somatic Cell and Molecular Genetics 27(1-6), 85-95.
  • Oupicky D., Ogris, M., Howard K. A., Dash P. R., Ulbrich K., Seymour L. W. (2002) Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation., Molecular Therapy, 5 (4), 463-472
  • Oupicky D., Ogris, M., Seymour LW (2002) Development of long-circulating polyelectrolyte complexes for systemic delivery of genes., J Drug Target 10(2, 93-98.
  • Ogris, M., Wagner, E. (2002) Targeting tumors with non-viral gene delivery systems., Drug Discovery Today 7 (8), 479-485.
  • Ogris, M., Carlisle RC., Bettinger T, Seymour LW (2001) Melittin enables efficient vesicular escape and enhanced nuclear access of non-viral gene delivery vectors, J. Biol. Chem.,276 (5), 47550-47555
  • Carlisle RC., Bettinger T., Ogris, M., Hale S., Mautner V, Seymour LW (2001) Adenovirus hexon protein enhances nuclear delivery and increases transgene expression of polyethylenimine/plasmid DNA vectors., Molecular Therapy, 4 (5), 473-483
  • Bettinger T., Carlisle RC., Read ML., Ogris, M., Seymour LW (2001) Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells., Nucleic Acids Research, 29 (18), 3882-91
  • Ogris, M., Steinlein P., Carotta S., Brunner S, Wagner, E. (2001) DNA/polyethylenimine transfection particles: Influence of ligands, polymer size and PEGylation on internalisation and gene expression., AAPS PharmSci, 3 (3), article 21.
  • Kircheis, R., Kursa, M., Wightman, L., Brunner, S., Ogris, M., Schüller, S., Wagner, E. (2000) Systemic in vivo gene delivery into tumors by the use of transferrin-polyethylenimine DNA complexes, NATO Science Series, A: Life Sciences, 323, 186-191.
  • Ogris, M., Wagner, E., Steinlein, P. (2000) A versatile assay to study cellular uptake of gene transfer complexes by flow cytometry, Biophys. Biochim. Acta 1474, 237-43.
  • Ogris, M., Brunner S., Schueller S., Kircheis R, Wagner, E. (1999) PEGylated DNA/Transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Therapy 6, 595-605.
  • Kircheis R., Schueller S., Brunner S., Ogris, M., Heider K-H., Zauner W, Wagner, E. (1999) Polycation-basedDNA complexes for tumor-targeted gene delivery in vivo., J. Gene Medicine 1, 111-120.
  • Zauner W., Brunner S., Buschle M., Ogris, M., Wagner, E. (1999) Differential behaviour of lipid based and polycation based gene transfer systems in transfecting primary human fibroblasts: a potential role of polylysine in nuclear transport., Biophys. Biochim. Acta 1428, 57-67.
  • Kircheis, R., Ogris, M., Brunner, S., Schüller, S., Wightman, L., Kursa, M., Wagner, E. (1999) Transferrin-polycation DNA complexes for tumor-targeted in vivo gene transfer. In: Progress in Drug Delivery Systems VIII, N. Oku, Ed., 83-94.
  • Ogris, M., Steinlein P., Kursa M., Mechtler K., Kircheis R, Wagner, E. (1998) The size of DNA/transferrin-PEI complexes is an important factor forgene expression in cultured cells., Gene Therapy 5, 1425-1433.
  • Kichler, A., Zauner, W., Ogris, M., Wagner, E. (1998) Influence of the DNA complexation medium on the transfection efficiency of lipospermine/DNA particles. Gene Therapy 5, 855-860.
  • Wagner, E., Ogris, M., Zauner, W. (1998) Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Del. Rev. 30, 97-113.
  • Talsma H., Cherng J., Lehrmann H., Kursa M., Ogris, M., Hennink WE., Cotten M, Wagner, E. (1997) Stabilization of gene delivery systems by freeze-drying., Int. J. Pharm. 157, 233-238
  • Kircheis R., Kichler A., Wallner G., Kursa M., Ogris, M., Felzmann T., Buchberger M, Wagner, E. (1997) Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery., Gene Therapy 4, 409-418
• Books

  • Nanotechnology for Nucleic Acid Delivery. Book series Methods in Molecular Biology, Volume 1943 (2019) Editors: Manfred Ogris, Haider Sami. ISBN: 978-1-4939-9092-4 (e-book); 978-1-4939-9091-7 (hardcover)
  • Nanotechnology for Nucleic Acid Delivery. Book series Methods in Molecular Biology, Volume 948 (2013) Editors: Manfred Ogris, David Oupicky. ISBN: 978-1-62703-139-4 (Print) 978-1-62703-140-0 (Online)
• Book Chapters and Volumes

  • Dohmen, C., Ogris, M. (2009) Receptor-Mediated Delivery of Proteins and Peptides to Tumors. In ‘Pharmaceutical Perspectives of Cancer Therapeutics.’ Mahato, RI and Lu, Y (Eds), Springer Science + Business Media, New York, pp 269-295
  • Ogris, M., Wagner, E. (2008) Linear Polyethylenimine: Synthesis and transfection procedures for in vitro and in vivo. In: ‘Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual.’ Friedmann, T and Rossi, J (Eds), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 521-526
  • Wagner, E., Ogris, M. (2007) Strategies to incorporate CPPs into synthetic viruses for tumor-targeted gene therapy. Chapter 26 in ?Cell-Penetrating Peptides, 2nd Edition, Ü. Langel (Ed.), CRC Press, pp 455-468.
  • Fahrmeir, J., Ogris, M. (2006) Transferrin receptor mediated delivery of protein and peptide drugs into tumors. Chapter in ‘Delivery of Protein and Peptide Drugs in Cancer ‘, V. Torchillin (Ed), World Scientific Publishing, pp 206-223.
  • Wagner, E., Klöckner, J., Ogris, M. (2005) Optimizing polyplexes into synthetic viruses for tumor-targeted gene therapy. Chapter in 'Non-viral Gene Therapy: Gene Design and Delivery', K. Taira , K. Kataoka , T. Niidome ( Eds. ), Springer-Verlag Tokyo , pp 237-245.
  • Ogris, M., von Gersdorff, K., van der Piepen, S., Brunner, S., Wagner, E. (2004) Non-viral gene delivery systems - delivery techniques and therapeutic concepts for cancer. Chapter 7 in 'Advanced Biomaterials for Medical Applications', D. W. Thomas ( Ed ), Kluwer Academic Publishers , pp 79-92.
  • Ogris, M. (2004) Polyethylenimine and Copolymers.. Chapter in 'Polymeric Gene Delivery: Principles and Application', Mansoor M. Amiji (Ed), CRC Press, Boca Raton (FL), pp 97-106.
  • Boeckle, S., Wagner, E., Ogris, M. (2002) Transmembrane Targeting of DNA with Membrane Active Peptides. Chapter 23 in 'Biomedical Aspects of Drug Targeting', V. R. Muzykantov , V. P. Torchilin ( Eds ), Kluwer Academic Publishers , Boston / Dordrecht / London , pp 441-458.
  • Kircheis, R., Kursa, M., Wightman, L., Brunner, S., Ogris, M., Schüller, S., Wagner, E. (2000) Systemic in vivo gene delivery into tumors by the use of transferrin-polyethylenimine DNA complexes. NATO Science Series, A: Life Sciences, 323, pp186-191.
  • Kircheis, R., Wightman, L., Ogris, M., Brunner, S., Kursa, M., Schüller, S., Wagner, E. (2000) Receptor -mediated gene transfer based on plasmid DNA complexes. Chapter in: Progress in Gene Therapy: Basic and Clinical Frontiers, Bertolotti, Parvez, Nagatsu Eds., VSP BV, pp183-203.
  • Kircheis, R., Ogris, M., Brunner, S., Schüller, S., Wightman L., Kursa M., Wagner, E. (1999) Transferrin-polycation DNA complexes for tumor-targeted in vivo gene transfer. In: Progress in Drug Delivery Systems VIII, N. Oku, Ed., pp 83-94.